Synercid ® I.V. (quinupristin and dalfopristin for injection) DESCRIPTION Synercid ® (quinupristin and dalfopristin powder for injection) I.V., a strep
NDA 50-747/S-008 NDA 50-748/S-008 Page 3 Synercid ® I.V. (quinupristin and dalfopristin for injection) One of Synercid's approved indications is for the treatment of patients with serious or life-threatening infections associated with vancomycin-resistant Enterococcus faecium (VREF) bacteremia.
Background & objectives : Since the incidence of vancomycin- and methicillin-resistant Gram-positive infections continue to increase, novel antimicrobials such as linezolid and streptogramin may provide new options to treat patients.
Interactions of quinupristin/dalfopristin with eight other antibiotics as measured by time-kill studies with 10 strains of Staphylococcus aureusfor which quinupristin/dalfopristin alone was not bactericidal.
A Performance Evaluation of Phoenix ™ Automated Microbiology System * in detecting resistance to Linezolid, Azithromycin, Clarithromycin and Quinupristin-dalfopristin among Staphylococcal and Enterococcal isolates J. REUBEN, D. TURNER, C. YU AND T. WILES BD Biosciences • 7 Loveton Circle ...
Results: Quinupristin-dalfopristin, linezolid, daptomycin, and tigecycline have excellent in vitro activity comparable to vancomycin for methicillin-resistant staphylococci and superior to vancomycin for vancomycin-resistant isolates.
Compared to quinupristin-dalfopristin and linezol-id, daptomycin was more active against penicillin-resistant Strept ococcus pneumoniae.
The level of inducible quinupristin-dalfopristin resistance was expressed as relative growth, defined as the 24-hopticaldensity (at 600 nm) of the isolate preexposed tovirginiamycin and challenged with quinupristin-dalfopristin divided by the optical density of the same isolate cultured in BHI broth for ...
Am J Respir Crit Care Med Vol 161. pp 753–762, 2000 Internet address: www.atsjournals.org Treatment of Gram-positive Nosocomial Pneumonia Prospective Randomized Comparison of Quinupristin/Dalfopristin
Over the next week, her platelet count increases back toward the admission value. ■ QUINUPRISTIN-DALFOPRISTIN FOR SERIOUS VREF INFECTIONS Quinupristin-dalfopristin consists of two streptogramins that inhibit protein synthesis by binding to the 50S subunit of the bacteria's ribosomes. 15 It is active ...