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Lrrk2

LRRK2 andParkinsonDisease

NEUROLOGICALREVIEW LRRK2 andParkinsonDisease JustusC.Dächsel,PhD;MatthewJ.Farrer,PhD Objectives:Toreviewthemoleculargeneticsandfunc tional biology of leucine-rich repeat kinase 2 (LRRK2)

Optimization of LanthaScreen™ Kinase Assays for LRRK2 and ...

1 Optimization of LanthaScreen™ Kinase Assays for LRRK2 and LRRK2 G2019S Overview This protocol describes how to develop a LanthaScreen ™ kinase assay designed to detect and characterize kinase inhibitors.

Inhibitors of LRRK2 kinase attenuate neurodegeneration and ...

2 ABSTRACT Mutations in LRRK2 have been identified as a genetic cause of familial Parkinson's disease (PD), and mutations in LRRK2 have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD.

Optimization of a LanthaScreen® Kinase assay for LRRK2 I2020T

Optimization of a LanthaScreen ® Kinase assay for LRRK2 I2020T Overview This protocol describes how to develop a LanthaScreen ® kinase assay designed to detect and characterize kinase inhibitors.

Leucine-rich repeat kinase 2 (LRRK2) interacts withparkin ...

Leucine-rich repeat kinase 2 (LRRK2) interacts withparkin, and mutant LRRK2 induces neuronal degeneration WanliW. Smith * † , Zhong Pei * † , Haibing Jiang * , Darren J. Moore ‡§, Yideng Liang*, Andrew B. West ‡§, ValinaL.

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause ...

doi:10.1093/brain/awh667 Brain (2005), 128, 2786–2796 Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson’s disease: clinical,

Poster 01

LRRK2 wild type and selected pathogenic mutants were transiently expressed in HEK293 cells, recombinant proteins were immunoprecipitated and kinase activity tested by autophosphorylation.

LanthaScreen™ Eu Kinase Binding Assay for LRRK2

LanthaScreen™ Eu Kinase Binding Assay Validation Packet Version No.: 1 Page 1 of 17 Optimization of a LanthaScreen™ Eu Kinase Binding Assay for LRRK2 Have a question?

The FamilialParkinsonism Gene LRRK2 Regulates Neurite Process ...

Neuron 52,587-593, November 22,2006ª2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.10.008 Report The FamilialParkinsonism Gene LRRK2 Regulates Neurite Process Morphology David MacLeod, 1 , 2 Julia Dowman, 1 , 2 Rachel Hammond, 1 , 2 Thomas Leete,1 Keiichi Inoue, 1 andAsa Abeliovich 1 , * 1 ...