Frequencies of both usual ductal and atypical hyperplasia (7.9% and 1.2%) were somewhat lower in our study than those found by Dupont et al 2 (13.7 % and 1.7%).
Usual ductal hyperplasia displays a luminal staining pattern with expression of both CK5/14 and CK7/18. Residual p63 was observed in the nuclei of the myoepithelium (photos 2/3).
While usual epithelial hyperplasia is morphologically and phenotypically heterogeneous, atypical ductal hyperplasia (ADH) and established ductal carcinoma in situ (DCIS) are homogeneous in cell type and marker expression.
Ductal Proliferations of the Breast: The Good, the Bad, and the Ugly Melinda F. Lerwill, MD CRITERIA FOR DISTINGUISHING LOW-GRADE DUCTAL CARCINOMA IN SITU FROM USUAL DUCTAL HYPERPLASIA CYTOLOGY Low-grade atypia Usual ductal hyperplasia Cell population Monomorphic Polymorphic Nuclear shape Round ...
Comparison of usual ductal hyperplasia (UDH) with atypical ductal hyperplasia (ADH) with immunostains. A, UDH (hematoxylin-eosin, original magnification 200).
Usual Ductal Hyperplasia WHO, 2003 • Architectural features-Irregular fenestrations-Peripheral fenestrations-Stretched or twisted epithelial bridges-Uneven distribution and overlapping of nuclei • Cellular features-Multiple cell types-Variation in appearance of epithelial cells-Indistinct cell ...
Discussion ADH The fundamental definition of ductal epithelial hyperplasia is an increase in the number of cells superior to the basement membrane beyond the usual two. "Usual" or "ordinary" ductal hyperplasia is the most common variety; it is characterized by proliferation of a heterogeneous ...
associated with malignant tumors, whereas usual ductal hyperplasia, adenosis, sclerosing adenosis, and (non sclerosing) papilloma were usually associated with
Only the most advanced lesion of the so-called usual ductal hyperplasias (mild, moderate or florid) was scored, i.e. if moderate and florid ductal hyperplasia were both present, only florid ductal hyperplasia was scored.
Florid ductal hyperplasia of usual type. The two ducts are filled by a mixed population of cells Figure 3. Continuum of change Epithelial hyperplasia Invasive carcinoma Ductal carcinoma in situ Atypical ductal hyperplasia